Design, Synthesis and Pharmacological Screening of 2-(2-(benzo [d] Oxazol-2-yl) Phenylamino)-n-(substituted Phenyl) Acetamides as Anti-inflammatory and Analgesic Agents
نویسندگان
چکیده
The endeavor of this study was to design, synthesize and investigate the in vivo anti-inflammatory and analgesic activity of some novel 2-(2-(benzo[d]oxazol-2-yl) phenylamino)-N-(substituted phenyl) acetamide (2A-2F) derivatives. 2-(2-aminophenyl) benzoxazole (D1) was synthesized by the condensation of anthranilic acid with starting material 2-aminophenol in the existence of poly phosphoric acid. A separate route was followed to obtain substituted chloroacetanilides (A1-A6) by the reaction of substituted anilines with chloroacetyl chloride. Finally title compounds were obtained by fusion of 2-(2-aminophenyl) benzoxazole (D1) and substituted chloroacetanilides (A1-A6). The newly synthesized compounds were characterized by IR, NMR and Mass spectral data. The title compounds were evaluated for in vivo anti-inflammatory and analgesic activities by carrageenan induced paw edema and acetic acid induced writhing method respectively. A few of the synthesized compounds manifest promising activity when compared to standard drug diclofenac sodium.
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